The U19 Center and Penn biosample bank that the Penn team has developed over the past 20 years will be a valuable resource to other investigators beyond Penn who pursue research on amyloid polymorphisms and strain. The Penn U19 Center innovates by elucidating mechanisms underlying the heterogeneous progression of cognitive impairment to dementia in LBD compared to AD+aSyn in addition to neurodegeneration mediated by progressive accumulation and cell-to-cell spread of pathological aSyn strains. Thus, the Penn U19 Center seeks to understand the molecular mechanisms that underlie AD+aSyn/LBD heterogeneity.
View Resource
