Penn Resources

The Penn Program on Precision Medicine for the Brain (P3MB) seeks to understand the inter-related clinical, ethical, and policy implications of applying precision medicine to the brain and to translate these discoveries into practice. The power of P3MB is its multidisciplinary collaborations. The work is made possible by grants from the Alzheimer’s Association, Centers for Disease Control and Prevention, National Institute on Aging, and generous philanthropic support.

The PTNC at the Perelman School of Medicine (PSOM) and Health System integrates Penn’s interdisciplinary, world-class neuroscience programs in patient care, education, and research by supporting pilot projects, clinical neuroscience initiatives, educational events, and start-up funding for junior faculty appointees in the clinical neurosciences. 

The Penn Medicine Translational Neuroscience Center (PTNC) is dedicated to accelerating and translating discoveries to transform the prevention, diagnosis and treatment of neuropsychiatric and neurological conditions. The PTNC works on initiatives around education, informatics, interdisciplinary research, and point of care research in the neuroscience domain. The center works closely with other The PTNC is working closely with Penn’s new Institute for Bioinformatics to create a neuro-informatics infrastructure to support translational research, and is developing a Translational Neuroscience Pipeline that facilitates industry partnerships. PTNC is also partnering with the Mahoney Institute for Neurosciences to enhance integration and synergies across the neurosciences at Penn.

The department of Neurology is committed to be a center of excellence and innovation dedicated to the pursuit of curing neurologic diseases through compassionate, patient-centered care, transformative research and education of the future leaders in neurology. The Department of Neurology has setup Translational Centers of Excellence (TCE). The goal of the TCE program is to support pilot projects to accelerate high impact areas, uniquely suited to the Department of Neurology, aiming towards self-sustainability. Four TCEs are currently active and two more will be added soon.

The Translational Neuropathology Research Laboratory seeks to understand the molecular causes of age-related neurodegenerative diseases, in particular frontotemporal degeneration (FTD), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Trauma-Related Neurodegeneration (TReND).  They use an interdisciplinary approach to address the mechanisms of neurodegeneration, including molecular, biochemical, histologic, physiologic and behavioral methods. They are also interested in using and developing cutting-edge techniques including multi-spectral confocal imaging, single cell RNA sequencing, spatial transcriptomics, CRISPR editing, and cryo-electron microscopy.